Kelland, Lloyd : rechercher sur Z-Library

Lloyd R. Kelland, Swee Y. Sharp, Ciaran F. O’Neill, Florence I. Raynaud, Philip J. Beale, Ian R. Judson

Année:

2001

Fichier:

PDF, 28 KB

2001

Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance

Journal:

Journal of Inorganic Biochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 180 KB

english, 1999

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug

Jane M Berry, Philip W Howard, Lloyd R Kelland, David E Thurston

Journal:

R. John Harrison, Sharon M. Gowan, Lloyd R. Kelland, Stephen Neidle

Année:

2002

Langue:

english

Fichier:

PDF, 116 KB

english, 2002

Human telomerase inhibition by substituted acridine derivatives

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 348 KB

english, 1999

Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay

G. W. Aherne, Anthea Hardcastle, Melanie Valenti, Alexander Bryant, Paul Rogers, George R. Pettit, Jayaram K. Srirangam, Lloyd R. Kelland

Journal:

Journal of Medicinal Chemistry

Année:

1996

Fichier:

PDF, 527 KB

1996

The resurgence of platinum-based cancer chemotherapy

Kelland, Lloyd

Journal:

Nature Reviews Cancer

Année:

2007

Langue:

english

Fichier:

PDF, 498 KB

english, 2007

A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor Activity

Mann, John, Baron, Anne, Opoku-Boahen, Yaw, Johansson, Eric, Parkinson, Gary, Kelland, Lloyd R., Neidle, Stephen

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 259 KB

english, 2001

Emerging drugs for ovarian cancer

Kelland, Lloyd R

Journal:

Expert Opinion on Emerging Drugs

Année:

2005

Langue:

english

Fichier:

PDF, 185 KB

english, 2005

Molecular Modeling Studies on G-Quadruplex Complexes of Telomerase Inhibitors: Structure−Activity Relationships

Read, Martin A., Wood, Alexis A., Harrison, John R., Gowan, Sharon M., Kelland, Lloyd R., Dosanjh, Harvinder S., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 581 KB

english, 1999

DNA Repair capacity and cisplatin sensitivity of human testis tumour cells

Beate Köberle, Keith A. Grimaldi, Andrew Sunters, John A. Hartley, Lloyd R. Kelland, John R.W. Masters

Journal:

Jeffrey Holford, Paul Rogers, Lloyd R. Kelland

Année:

1997

Langue:

english

Fichier:

PDF, 96 KB

english, 1997

ras mutation and platinum resistance in human ovarian carcinomas in vitro

Journal:

Katharine E. Pestell, Clare J. Medlow, Jenny C. Titley, Lloyd R. Kelland, Michael I. Walton

Année:

1998

Langue:

english

Fichier:

PDF, 163 KB

english, 1998

Characterisation of the P53 status, BCL-2 expression and radiation and platinum drug sensitivity of a panel of human ovarian cancer cell lines

Journal:

Angewandte Chemie International Edition

Année:

1998

Langue:

english

Fichier:

PDF, 124 KB

english, 1998

A Synthetic Azinomycin Analogue with Demonstrated DNA Cross-Linking Activity: Insights into the Mechanism of Action of this Class of Antitumor Agent

John A. Hartley, Ali Hazrati, Lloyd R. Kelland, Ruzwana Khanim, Michael Shipman, Franck Suzenet, Louise F. Walker

Journal:

Angewandte Chemie

Année:

2000

Langue:

english

Fichier:

PDF, 102 KB

english, 2000

A Synthetic Azinomycin Analogue with Demonstrated DNA Cross-Linking Activity: Insights into the Mechanism of Action of this Class of Antitumor Agent

John A. Hartley, Ali Hazrati, Lloyd R. Kelland, Ruzwana Khanim, Michael Shipman, Franck Suzenet, Louise F. Walker

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 102 KB

english, 2000

ChemInform Abstract: Synthesis of a Novel C2/C2′-exo Unsaturated Pyrrolobenzodiazepine Cross-Linking Agent with Remarkable DNA Binding Affinity and Cytotoxicity.

Stephen J. Gregson, Philip W. Howard, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Année:

1999

Fichier:

PDF, 40 KB

1999

ChemInform Abstract: Symmetric Bis-benzimidazoles: New Sequence-Selective DNA-Binding Molecules.

Stephen Neidle, John Mann, Emma L. Rayner, Anne Baron, Yaw Opoku-Boahen, Ian J. Simpson, Nicola J. Smith, Keith R. Fox, John A. Hartley, Lloyd R. Kelland

Journal:

Timothy J. Hodgkinson, Lloyd R. Kelland, Michael Shipman, Franck Suzenet

Année:

1999

Fichier:

PDF, 32 KB

1999

ChemInform Abstract: Chemical Synthesis and Cytotoxicity of Some Azinomycin Analogues Devoid of the 1-Azabicyclo[3.1.0]hexane Subunit.

Journal:

Stephen J. Gregson, Philip W. Howard, Simona Barcella, Anthonia Nakamya, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Année:

2000

Fichier:

PDF, 33 KB

2000

ChemInform Abstract: Effect of C2/C3-endo Unsaturation on the Cytotoxicity and DNA-Binding Reactivity of Pyrrolo[2,1-c][1,4]benzodiazepines.

Journal:

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Simona Barcella, Maqsood M. Yasin, Abigail A. Hurst, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Année:

2000

Fichier:

PDF, 35 KB

2000

ChemInform Abstract: Effect of C2-exo Unsaturation on the Cytotoxicity and DNA-Binding Reactivity of Pyrrolo[2,1-c][1,4]benzodiazepines.

Journal:

Année:

2000

Fichier:

PDF, 35 KB

2000

ChemInform Abstract: A Novel Inhibitor of Human Telomerase Derived from 10H-Indolo[3,2-b]quinoline.

Vittorio Caprio, Berengere Guyen, Yaw Opoku-Boahen, John Mann, Sharon M. Gowan, Lloyd M. Kelland, Martin A. Read, Stephen Neidle

Journal:

Ippolito Antonini, Paolo Polucci, Lloyd R. Kelland, Silvano Spinelli, Nicoletta Pescalli, Sante Martelli

Année:

2000

Fichier:

PDF, 30 KB

2000

ChemInform Abstract: N4-(ω-Aminoalkyl)-1- [(ω-aminoalkyl)amino]-4-acridinecarboxamides: Novel, Potent, Cytotoxic, and DNA-Binding Agents.

Journal:

Année:

2001

Fichier:

PDF, 30 KB

2001

ChemInform Abstract: Synthesis, Cytotoxicity and DNA Cross-Linking Activity of Symmetrical Dimers Based Upon the Epoxide Domain of the Azinomycins.

John A. Hartley, Ali Hazrati, Timothy J. Hodgkinson, Lloyd R. Kelland, Ruzwana Khanim, Michael Shipman, Franck Suzenet

Journal:

Stephen J. Gregson, Philip W. Howard, John A. Hartley, Natalie A. Brooks, Lesley J. Adams, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Année:

2001

Fichier:

PDF, 28 KB

2001

ChemInform Abstract: Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity.

Journal:

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Année:

2001

Fichier:

PDF, 34 KB

2001

ChemInform Abstract: Synthesis of the First Example of a C2-C3/C2′-C3′-endo Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepine Dimer.

Journal:

Jane M. Berry, Philip W. Howard, Lloyd R. Kelland, David E. Thurston

Année:

2002

Fichier:

PDF, 29 KB

2002

Synthesis and Biological Evaluation of an N10-Psec Substituted Pyrrolo[2,1-c][1,4]benzodiazepine Prodrug.

Journal:

Michael D. Urbaniak, Lisa M. Frost, John P. Bingham, Lloyd R. Kelland, John A. Hartley, Derek N. Woolfson, Stephen Caddick

Année:

2002

Fichier:

PDF, 31 KB

2002

Chemical Synthesis and Cytotoxicity of Dihydroxylated Cyclopentenone Analogues of Neocarzinostatin Chromophore.

Journal:

Année:

2003

Fichier:

PDF, 119 KB

2003

Overexpression of BclXL in a human ovarian carcinoma cell line: Paradoxic effects on chemosensitivity in vitro versus in vivo

Paul M. Rogers, Philip J. Beale, Mansour Al-Moundhri, Frances Boxall, Lisa Patterson, Melanie Valenti, Florence Raynaud, Steve Hobbs, Stephen Johnston, Lloyd R. Kelland

Journal:

Liangli Zhao, Lai-Ming Ching, Philip Kestell, Lloyd R. Kelland, Bruce C. Baguley

Année:

2002

Langue:

english

Fichier:

PDF, 238 KB

english, 2002

Mechanisms of tumor vascular shutdown induced by 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Increased tumor vascular permeability

Journal:

Prakash Mistry, Swee Y. Loh, Lloyd R. Kelland, Ken R. Harrap

Année:

2005

Langue:

english

Fichier:

PDF, 92 KB

english, 2005

Effect of buthionine sulfoximine on PtII and PtIV drug accumulation and the formation of glutathione conjugates in human ovarian-carcinoma cell lines

Journal:

Kirste J. Mellish, Chris F. J. Barnard, Lloyd R. Kelland, Ken R. Harrap

Année:

1993

Langue:

english

Fichier:

PDF, 752 KB

english, 1993

Circumvention of acquired tetraplatin resistance in a human ovarian carcinoma cell line by a novel Trans platinum complex, JM335 [Trans ammine (cyclohexylamine) dichloro dihydroxo platinum (IV)]

Journal:

Kirste J. Mellish, Christopher F. J. Barnard, Barry A. Murrer, Lloyd R. Kelland

Année:

1994

Langue:

english

Fichier:

PDF, 775 KB

english, 1994

DNA-binding properties of novel cis- and trans platinum-based anticancer agents in 2 human ovarian carcinoma cell lines

Journal:

Critical Reviews in Oncology/Hematology

Année:

1995

Langue:

english

Fichier:

PDF, 760 KB

english, 1995

New platinum antitumor complexes

Lloyd R. Kelland

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 3.59 MB

english, 1993

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding

R. John Harrison, Anthony P. Reszka, Shozeb M. Haider, Barbara Romagnoli, James Morrell, Martin A. Read, Sharon M. Gowan, Christopher M. Incles, Lloyd R. Kelland, Stephen Neidle

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 293 KB

english, 2004

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents

Cristina Martins, Mekala Gunaratnam, John Stuart, Vaidahi Makwana, Olga Greciano, Anthony P. Reszka, Lloyd R. Kelland, Stephen Neidle

Journal:

Timothy J. Hodgkinson, Lloyd R. Kelland, Michael Shipman, Julia Vile

Année:

2007

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2007

Synthesis and reactivity of some chiral, nonracemic 1-azabicyclo[4.1.0]heptanes related to the azinomycins

Journal:

Tetrahedron

Année:

1998

Langue:

english

Fichier:

PDF, 441 KB

english, 1998

Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substituents: Crystal and molecular structure of [PtL4Cl2]·H2O where L4 is ethylenediamine-N,N′-diacetate

Joseph N Jolley, Alexander I Yanovsky, Lloyd R Kelland, Kevin B Nolan

Journal:

Journal of Inorganic Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 656 KB

english, 2001

Effect of C2/C3-endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Simona Barcella, Anthonia Nakamya, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Simona Barcella, Maqsood M. Yasin, Abigail A. Hurst, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Année:

2000

Langue:

english

Fichier:

PDF, 165 KB

english, 2000

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 158 KB

english, 2000

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline

Vittorio Caprio, Berengere Guyen, Yaw Opoku-Boahen, John Mann, Sharon M Gowan, Lloyd M Kelland, Martin A Read, Stephen Neidle

Journal:

Stephen J Gregson, Philip W Howard, Kathryn E Corcoran, Terence C Jenkins, Lloyd R Kelland, David E Thurston

Année:

2000

Langue:

english

Fichier:

PDF, 186 KB

english, 2000

Synthesis of the first example of a c2-C3/C2′-C3′-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 130 KB

english, 2001

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

Michael D Urbaniak, Lisa M Frost, John P Bingham, Lloyd R Kelland, John A Hartley, Derek N Woolfson, Stephen Caddick

Journal:

Timothy J. Hodgkinson, Lloyd R. Kelland, Michael Shipman, Franck Suzenet

Année:

2003

Langue:

english

Fichier:

PDF, 128 KB

english, 2003

Chemical synthesis and cytotoxicity of some azinomycin analogues devoid of the 1-azabicyclo[3.1.0]hexane subunit

Journal:

European Journal of Clinical Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 129 KB

english, 2000

Book review

Lloyd R. Kèlland

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 224 KB

english, 1996

Comparative in vitro cytotoxicity of taxol and Taxotere against cisplatin-sensitive and-resistant human ovarian carcinoma cell lines

Lloyd R. Kelland, George Abel

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 801 KB

english, 1992

Human ovarian-carcinoma cell lines and companion xenografts: a disease-oriented approach to new platinum anticancer drug discovery

Lloyd R. Kelland, Mervyn Jones, George Abel, Melanie Valenti, Jean Gwynne, Kenneth R. Harrap

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Année:

1992

Langue:

english

Fichier:

PDF, 832 KB

english, 1992

Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET

Jason S. Lewis, Jason L. J. Dearling, Jane K. Sosabowski, Jamal Zweit, Paul Carnochan, Lloyd R. Kelland, Helen M. Coley, Philip J. Blower

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 145 KB

english, 2000

cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell lines

Michael G. Ormerod, Ciaran O’Neill, David Robertson, Lloyd R. Kelland, Kenneth R. Harrap

Journal: